| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
|---|
| Ligand | BDBM50358778 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_789778 (CHEMBL1924994) |
|---|
| Ki | 0.14±n/a nM |
|---|
| Citation |  Ivachtchenko, AV; Golovina, ES; Kadieva, MG; Kysil, VM; Mitkin, OD; Tkachenko, SE; Okun, IM Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists. J Med Chem54:8161-73 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 6 |
|---|
| Name: | 5-hydroxytryptamine receptor 6 |
|---|
| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46968.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P50406 |
|---|
| Residue: | 440 |
|---|
| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
|
|
|
|---|
| BDBM50358778 |
|---|
| n/a |
|---|
| Name | BDBM50358778 |
|---|
| Synonyms: | CHEMBL1922616 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14ClN5O2S |
|---|
| Mol. Mass. | 351.811 |
|---|
| SMILES | CNc1nn2c(N)c(Cl)c(C)nc2c1S(=O)(=O)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
