Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50328724 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_790745 (CHEMBL1926198) |
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IC50 | 7±n/a nM |
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Citation | Shi, Y; O'Connor, SP; Sitkoff, D; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Li, C; Ruan, Z; Lawrence, RM; Klei, HE; Kish, K; Liu, EC; Seiler, SM; Schweizer, L; Steinbacher, TE; Schumacher, WA; Robl, JA; Macor, JE; Atwal, KS; Stein, PD Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. Bioorg Med Chem Lett21:7516-21 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50328724 |
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n/a |
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Name | BDBM50328724 |
Synonyms: | (S)-N2,N2-dimethyl-N5-((2-methylbenzofuran-5-ylamino)(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-ylamino)methylene)pyridine-2,5-dicarboxamide | BMS-344577 | CHEMBL570867 |
Type | Small organic molecule |
Emp. Form. | C31H37N7O5 |
Mol. Mass. | 587.6694 |
SMILES | CN(C)C(=O)c1ccc(cn1)C(=O)NC(Nc1ccc2oc(C)cc2c1)=N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O |r,w:14.14| |
Structure |
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