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TargetCoagulation factor VII
LigandBDBM50358883
Substrate/Competitorn/a
Meas. Tech.ChEMBL_790753
Ki 3684±n/a nM
Citation Shi YO'Connor SPSitkoff DZhang JShi MBisaha SNWang YLi CRuan ZLawrence RMKlei HEKish KLiu ECSeiler SMSchweizer LSteinbacher TESchumacher WARobl JAMacor JEAtwal KSStein PD Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. Bioorg Med Chem Lett 21:7516-21 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor VII
Name:Thrombin and coagulation factor VII
Synonyms:Eptacog alfa | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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  Blast E-value cutoff:
BDBM50358883
n/a
NameBDBM50358883
Synonyms:CHEMBL1923468
TypeSmall organic molecule
Emp. Form.C28H29ClN4O5S
Mol. Mass.569.072
SMILESClc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Structure
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