| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50358883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_790755 (CHEMBL1926208) |
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| Ki | 1279±n/a nM |
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| Citation |  Shi, Y; O'Connor, SP; Sitkoff, D; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Li, C; Ruan, Z; Lawrence, RM; Klei, HE; Kish, K; Liu, EC; Seiler, SM; Schweizer, L; Steinbacher, TE; Schumacher, WA; Robl, JA; Macor, JE; Atwal, KS; Stein, PD Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. Bioorg Med Chem Lett21:7516-21 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50358883 |
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| n/a |
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| Name | BDBM50358883 |
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| Synonyms: | CHEMBL1923468 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29ClN4O5S |
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| Mol. Mass. | 569.072 |
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| SMILES | Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r| |
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| Structure | 
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