Reaction Details |
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Target | Renin |
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Ligand | BDBM50359188 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_789822 (CHEMBL1925083) |
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IC50 | 2.5±n/a nM |
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Citation | Chen, A; Aspiotis, R; Campeau, LC; Cauchon, E; Chefson, A; Ducharme, Y; Falgueyret, JP; Gagné, S; Han, Y; Houle, R; Laliberté, S; Larouche, G; Lévesque, JF; McKay, D; Percival, D Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines. Bioorg Med Chem Lett21:7399-404 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50359188 |
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n/a |
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Name | BDBM50359188 |
Synonyms: | CHEMBL1923125 |
Type | Small organic molecule |
Emp. Form. | C26H25F2N3O2 |
Mol. Mass. | 449.4924 |
SMILES | Fc1cc2CO[C@@]3(CCNC[C@@H]3C(=O)N(Cc3cccc4cccnc34)C3CC3)c2cc1F |r| |
Structure |
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