| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50359487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_792600 (CHEMBL1930241) |
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| IC50 | 0.2±n/a nM |
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| Citation |  Skerlj, R; Bridger, G; Zhou, Y; Bourque, E; McEachern, E; Langille, J; Harwig, C; Veale, D; Yang, W; Li, T; Zhu, Y; Bey, M; Baird, I; Sartori, M; Metz, M; Mosi, R; Nelson, K; Bodart, V; Wong, R; Fricker, S; Mac Farland, R; Huskens, D; Schols, D Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication. Bioorg Med Chem Lett21:6950-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50359487 |
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| n/a |
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| Name | BDBM50359487 |
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| Synonyms: | CHEMBL1926893 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H40ClN5O2 |
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| Mol. Mass. | 550.135 |
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| SMILES | COc1ccc(cc1)N(Cc1cnccc1C)C1CCN(CC1)[C@H](C)CCNC(=O)c1c(C)cc(Cl)nc1C |r| |
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| Structure | 
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