Reaction Details |
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Target | NADPH oxidase 4 |
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Ligand | BDBM50359527 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_792879 (CHEMBL1931064) |
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Ki | 144±n/a nM |
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Citation | Gaggini, F; Laleu, B; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem19:6989-99 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NADPH oxidase 4 |
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Name: | NADPH oxidase 4 |
Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
Type: | PROTEIN |
Mol. Mass.: | 66954.54 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_792879 |
Residue: | 578 |
Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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BDBM50359527 |
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n/a |
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Name | BDBM50359527 |
Synonyms: | CHEMBL1927148 |
Type | Small organic molecule |
Emp. Form. | C24H24N4O3 |
Mol. Mass. | 416.4724 |
SMILES | COc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccc4)Cc3c2c1=O |
Structure |
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