| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50314839 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_793312 (CHEMBL1931815) |
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| Ki | 2100±n/a nM |
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| Citation |  Van Poecke, S; Munier-Lehmann, H; Helynck, O; Froeyen, M; Van Calenbergh, S Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. Bioorg Med Chem19:7603-11 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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| BDBM50314839 |
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| n/a |
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| Name | BDBM50314839 |
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| Synonyms: | 3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | CHEMBL1089867 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClN5O4 |
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| Mol. Mass. | 403.82 |
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| SMILES | Cc1cn([C@H]2C[C@@H]([C@@H](CO)O2)n2cc(nn2)-c2ccc(Cl)cc2)c(=O)[nH]c1=O |r| |
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| Structure | 
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