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TargetThymidylate kinase
LigandBDBM50314837
Substrate/Competitorn/a
Meas. Tech.ChEMBL_793312
Ki 2700±n/a nM
Citation Van Poecke SMunier-Lehmann HHelynck OFroeyen MVan Calenbergh S Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. Bioorg Med Chem 19:7603-11 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidylate kinase
Name:Thymidylate kinase
Synonyms:TMPK | Thymidine monophosphate kinase | dTMP kinase
Type:PROTEIN
Mol. Mass.:22636.29
Organism:Mycobacterium tuberculosis
Description:ChEMBL_208218
Residue:214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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  Blast E-value cutoff:
BDBM50314837
n/a
NameBDBM50314837
Synonyms:3'-(4-Benzyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | 3'-(4-Benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | CHEMBL1090133
TypeSmall organic molecule
Emp. Form.C19H21N5O4
Mol. Mass.383.4011
SMILESCc1cn([C@H]2C[C@@H]([C@@H](CO)O2)n2cc(Cc3ccccc3)nn2)c(=O)[nH]c1=O |r|
Structure
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