Reaction Details |
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Target | Hypoxanthine-guanine phosphoribosyltransferase |
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Ligand | BDBM50360111 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_793806 (CHEMBL1932721) |
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Ki | >100000±n/a nM |
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Citation | Cesnek, M; Hocková, D; Holý, A; Dracínský, M; Baszczynski, O; Jersey, Jd; Keough, DT; Guddat, LW Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorg Med Chem20:1076-89 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxanthine-guanine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine phosphoribosyltransferase |
Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
Type: | Protein |
Mol. Mass.: | 24579.61 |
Organism: | Homo sapiens (Human) |
Description: | P00492 |
Residue: | 218 |
Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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BDBM50360111 |
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n/a |
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Name | BDBM50360111 |
Synonyms: | CHEMBL1928780 |
Type | Small organic molecule |
Emp. Form. | C8H11N4O4P |
Mol. Mass. | 258.1711 |
SMILES | OP(O)(=O)CCCn1cnc2c1nc[nH]c2=O |
Structure |
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