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TargetHypoxanthine-guanine phosphoribosyltransferase
LigandBDBM50039559
Substrate/Competitorn/a
Meas. Tech.ChEMBL_793806 (CHEMBL1932721)
Ki 500±n/a nM
Citation Cesnek, MHocková, DHolý, ADracínský, MBaszczynski, OJersey, JdKeough, DTGuddat, LW Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorg Med Chem20:1076-89 (2012) [PubMed]  Article
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Hypoxanthine-guanine phosphoribosyltransferase
Name:Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:Protein
Mol. Mass.:24579.61
Organism:Homo sapiens (Human)
Description:P00492
Residue:218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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  Blast E-value cutoff:
BDBM50039559
n/a
NameBDBM50039559
Synonyms:CHEMBL267803 | [5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-pentyl]-phosphonic acid
TypeSmall organic molecule
Emp. Form.C10H16N5O4P
Mol. Mass.301.2389
SMILESNc1nc2n(CCCCCP(O)(O)=O)cnc2c(=O)[nH]1
Structure
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