Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHypoxanthine-guanine phosphoribosyltransferase
LigandBDBM50360120
Substrate/Competitorn/a
Meas. Tech.ChEMBL_793806 (CHEMBL1932721)
Ki>100000±n/a nM
Citation Cesnek, MHocková, DHolý, ADracínský, MBaszczynski, OJersey, JdKeough, DTGuddat, LW Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorg Med Chem20:1076-89 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hypoxanthine-guanine phosphoribosyltransferase
Name:Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:Protein
Mol. Mass.:24579.61
Organism:Homo sapiens (Human)
Description:P00492
Residue:218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50360120
n/a
NameBDBM50360120
Synonyms:CHEMBL1928931
TypeSmall organic molecule
Emp. Form.C12H19N4O4P
Mol. Mass.314.2774
SMILESOP(O)(=O)CCCCCCCn1cnc2c1nc[nH]c2=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: