Reaction Details |
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Target | Glutamate carboxypeptidase 2 |
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Ligand | BDBM50304738 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_794160 (CHEMBL1931945) |
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Ki | 1.08±n/a nM |
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Citation | Plechanovová, A; Byun, Y; Alquicer, G; Skultétyová, L; Mloochová, P; Nemcová, A; Kim, HJ; Navrátil, M; Mease, R; Lubkowski, J; Pomper, M; Konvalinka, J; Rulíšek, L; Barinka, C Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity. J Med Chem54:7535-46 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutamate carboxypeptidase 2 |
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Name: | Glutamate carboxypeptidase 2 |
Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
Type: | PROTEIN |
Mol. Mass.: | 84333.66 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1497035 |
Residue: | 750 |
Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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BDBM50304738 |
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n/a |
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Name | BDBM50304738 |
Synonyms: | 2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedioic acid | CHEMBL596351 | US20230414794, Compound ZJ-43 |
Type | Small organic molecule |
Emp. Form. | C12H20N2O7 |
Mol. Mass. | 304.2964 |
SMILES | CC(C)C[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O |r| |
Structure |
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