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TargetCytochrome P450 1A1
LigandBDBM50360379
Substrate/Competitorn/a
Meas. Tech.ChEMBL_795896
Ki 5370.32±n/a nM
Citation McNulty JNair JJVurgun NDifrancesco BRBrown CETsoi BCrankshaw DJHolloway AC Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). Bioorg Med Chem Lett 22:718-22 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 1A1
Name:Cytochrome P450 1A
Synonyms:CYPIA1 | Cytochrome P450 1A | Cytochrome P450 1A1 (CYP1A1) | P450 form 6 | P450-C | P450-P1
Type:Protein
Mol. Mass.:58177.23
Organism:Homo sapiens (Human)
Description:P04798
Residue:512
Sequence:
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
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  Blast E-value cutoff:
BDBM50360379
n/a
NameBDBM50360379
Synonyms:CHEMBL1933692
TypeSmall organic molecule
Emp. Form.C17H15N3O
Mol. Mass.277.3205
SMILESO=C(C(Cn1ccnn1)c1ccccc1)c1ccccc1
Structure
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