| Reaction Details |
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 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
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| Ligand | BDBM50360605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_795645 (CHEMBL1936075) |
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| IC50 | >30000±n/a nM |
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| Citation |  Powell, NA; Kohrt, JT; Filipski, KJ; Kaufman, M; Sheehan, D; Edmunds, JE; Delaney, A; Wang, Y; Bourbonais, F; Lee, DY; Schwende, F; Sun, F; McConnell, P; Catana, C; Chen, H; Ohren, J; Perrin, LA Novel and selective spiroindoline-based inhibitors of Sky kinase. Bioorg Med Chem Lett22:190-3 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
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| Name: | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
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| Synonyms: | I kappa-B kinase epsilon | I-kappa-B Kinase 3 (IKK-epsilon) | I-kappa-B kinase epsilon (IKK-E) | I-kappa-B kinase epsilon (IKKE) | IKBKE | IKK-E | IKK-epsilon | IKK-i | IKKE | IKKE_HUMAN | IKKI | Inducible I kappa-B kinase | KIAA0151 | von Hippel-Lindau disease tumor suppressor/Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 80475.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Kinase inhibitory activity was determined using recombinant human IKK-epsilon expressed in baculovirus as a FLAG-tagged fusion protein. |
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| Residue: | 716 |
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| Sequence: | MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
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| BDBM50360605 |
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| n/a |
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| Name | BDBM50360605 |
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| Synonyms: | CHEMBL1933538 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27FN4O |
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| Mol. Mass. | 418.5065 |
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| SMILES | Fc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCCNC2)c2ccccc12 |r| |
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| Structure | 
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