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TargetTyrosine-protein kinase
LigandBDBM50360613
Substrate/Competitorn/a
Meas. Tech.ChEMBL_795546 (CHEMBL1935924)
IC50 27900±n/a nM
Citation Powell, NAKohrt, JTFilipski, KJKaufman, MSheehan, DEdmunds, JEDelaney, AWang, YBourbonais, FLee, DYSchwende, FSun, FMcConnell, PCatana, CChen, HOhren, JPerrin, LA Novel and selective spiroindoline-based inhibitors of Sky kinase. Bioorg Med Chem Lett22:190-3 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase
Name:Tyrosine-protein kinase
Synonyms:Syk protein
Type:PROTEIN
Mol. Mass.:71353.61
Organism:Mus musculus
Description:ChEMBL_795546
Residue:629
Sequence:
MAGSAVDSANHLTYLFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA
HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNRPPGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT
VLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV
EHYSYKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYSFPKPGHKKP
APPQGSRPESTVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD
RSLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ
LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE
ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY
YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN
LCWTYDVENRPGFTAVELRLRNYYYDVVN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50360613
n/a
NameBDBM50360613
Synonyms:CHEMBL1933542
TypeSmall organic molecule
Emp. Form.C26H28FN3O
Mol. Mass.417.5184
SMILESFc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCCCC2)c2ccccc12 |r|
Structure
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