| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase |
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| Ligand | BDBM50360620 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_795546 (CHEMBL1935924) |
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| IC50 | 560±n/a nM |
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| Citation |  Powell, NA; Kohrt, JT; Filipski, KJ; Kaufman, M; Sheehan, D; Edmunds, JE; Delaney, A; Wang, Y; Bourbonais, F; Lee, DY; Schwende, F; Sun, F; McConnell, P; Catana, C; Chen, H; Ohren, J; Perrin, LA Novel and selective spiroindoline-based inhibitors of Sky kinase. Bioorg Med Chem Lett22:190-3 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase |
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| Name: | Tyrosine-protein kinase |
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| Synonyms: | Syk protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71353.61 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_795546 |
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| Residue: | 629 |
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| Sequence: | MAGSAVDSANHLTYLFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA
HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNRPPGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT
VLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV
EHYSYKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYSFPKPGHKKP
APPQGSRPESTVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD
RSLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ
LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE
ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY
YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN
LCWTYDVENRPGFTAVELRLRNYYYDVVN
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| BDBM50360620 |
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| n/a |
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| Name | BDBM50360620 |
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| Synonyms: | CHEMBL1933549 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClN4O |
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| Mol. Mass. | 420.935 |
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| SMILES | Clc1cccc2[nH]c(cc12)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12 |r| |
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| Structure | 
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