| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50360899 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_795469 (CHEMBL1937474) |
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| Ki | 4±n/a nM |
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| Citation |  Hudkins, RL; Aimone, LD; Dandu, RR; Dunn, D; Gruner, JA; Huang, Z; Josef, KA; Lyons, JA; Mathiasen, JR; Tao, M; Zulli, AL; Raddatz, R 4,5-dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists. Bioorg Med Chem Lett22:194-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50360899 |
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| n/a |
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| Name | BDBM50360899 |
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| Synonyms: | CHEMBL1935110 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27N3O2 |
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| Mol. Mass. | 329.4366 |
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| SMILES | C[C@@H]1CCCN1CCCOc1ccc(cc1)C1=NNC(=O)C(C)C1 |r,t:18| |
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| Structure | 
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