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TargetMacrophage metalloelastase
LigandBDBM50360952
Substrate/Competitorn/a
Meas. Tech.ChEMBL_796143 (CHEMBL1937507)
IC50 1.6±n/a nM
Citation Wu, YLi, JWu, JMorgan, PXu, XRancati, FVallese, SRaveglia, LHotchandani, RFuller, NBard, JCunningham, KFish, SKrykbaev, RTam, SGoldman, SJWilliams, CMansour, TSSaiah, ESypek, JLi, W Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett22:138-43 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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  Blast E-value cutoff:
BDBM50360952
n/a
NameBDBM50360952
Synonyms:CHEMBL1935300
TypeSmall organic molecule
Emp. Form.C22H21N3O6S
Mol. Mass.455.484
SMILESCC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1noc(n1)C1CC1)C(O)=O |r|
Structure
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