Reaction Details |
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Target | Histamine H4 receptor |
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Ligand | BDBM50361012 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_796037 (CHEMBL1936570) |
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Ki | 23±n/a nM |
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Citation | Smits, RA; Lim, HD; van der Meer, T; Kuhne, S; Bessembinder, K; Zuiderveld, OP; Wijtmans, M; de Esch, IJ; Leurs, R Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics. Bioorg Med Chem Lett22:461-7 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H4 receptor |
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Name: | Histamine H4 receptor |
Synonyms: | HH4R | HRH4_MOUSE | Hrh4 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44272.75 |
Organism: | Mus musculus (mouse) |
Description: | Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay. |
Residue: | 391 |
Sequence: | MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAIS
DFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAV
SYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTIT
MLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSN
PGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRG
RKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLY
PLCHRRFQKAFWKILCVTKQPALSQNQSVSS
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BDBM50361012 |
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n/a |
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Name | BDBM50361012 |
Synonyms: | CHEMBL1935574 |
Type | Small organic molecule |
Emp. Form. | C16H17N5O |
Mol. Mass. | 295.3391 |
SMILES | Nc1nc(N2CCNCC2)c2ccc(cc2n1)-c1ccco1 |
Structure |
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