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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H4 receptor | ||
| Ligand | BDBM50361022 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_795785 (CHEMBL1936672) | ||
| Ki | 221±n/a nM | ||
| Citation |  Smits, RA; Lim, HD; van der Meer, T; Kuhne, S; Bessembinder, K; Zuiderveld, OP; Wijtmans, M; de Esch, IJ; Leurs, R Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics. Bioorg Med Chem Lett22:461-7 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H4 receptor | |||
| Name: | Histamine H4 receptor | ||
| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 44517.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. | ||
| Residue: | 390 | ||
| Sequence: |
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| BDBM50361022 | |||
| n/a | |||
| Name | BDBM50361022 | ||
| Synonyms: | CHEMBL1935558 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25N5 | ||
| Mol. Mass. | 347.4567 | ||
| SMILES | CN1CCN(CC1)c1nc(N)nc2c(cccc12)-c1c(C)cccc1C |(-3.46,5.07,;-3.46,3.53,;-2.13,2.76,;-2.13,1.23,;-3.46,.46,;-4.8,1.22,;-4.8,2.76,;-3.46,-1.07,;-2.12,-1.84,;-2.12,-3.39,;-.78,-4.15,;-3.45,-4.16,;-4.79,-3.39,;-6.11,-4.15,;-7.45,-3.39,;-7.45,-1.84,;-6.11,-1.08,;-4.78,-1.85,;-6.11,-5.69,;-4.78,-6.45,;-3.45,-5.68,;-4.77,-7.99,;-6.11,-8.77,;-7.45,-8,;-7.45,-6.46,;-8.78,-5.69,)| | ||
| Structure | 
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