| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK3 |
|---|
| Ligand | BDBM50361096 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_795023 (CHEMBL1936403) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I 5-(2-amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitors. Bioorg Med Chem Lett22:96-101 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PLK3 |
|---|
| Name: | Serine/threonine-protein kinase PLK3 |
|---|
| Synonyms: | CNK | Cytokine-inducible serine/threonine-protein kinase | FGF-inducible kinase | FNK | PLK3 | PLK3_HUMAN | PRK | Polo-Like Kinase 3 | Proliferation-related kinase | Serine/threonine-protein kinase PLK3 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 71655.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Enzyme assays were using PLK3 purified from baculovirus-infected Trichoplusia ni cells expressing full-length PLK3. |
|---|
| Residue: | 646 |
|---|
| Sequence: | MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP
LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
|
|
|
|---|
| BDBM50361096 |
|---|
| n/a |
|---|
| Name | BDBM50361096 |
|---|
| Synonyms: | CHEMBL1933585 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H34F3N7O4 |
|---|
| Mol. Mass. | 601.62 |
|---|
| SMILES | CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc3c(CCN(C(=O)OC(C)(C)C)C3=O)n2C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
