| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek6 |
|---|
| Ligand | BDBM50361088 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_795101 (CHEMBL1936527) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I 5-(2-amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitors. Bioorg Med Chem Lett22:96-101 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Nek6 |
|---|
| Name: | Serine/threonine-protein kinase Nek6 |
|---|
| Synonyms: | NEK kinase | NEK6 | NEK6_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35724.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1446777 |
|---|
| Residue: | 313 |
|---|
| Sequence: | MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVY
KATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNI
VLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFI
TATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM
AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVH
QVAKQMHIWMSST
|
|
|
|---|
| BDBM50361088 |
|---|
| n/a |
|---|
| Name | BDBM50361088 |
|---|
| Synonyms: | CHEMBL1933582 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26F3N7O2 |
|---|
| Mol. Mass. | 501.5041 |
|---|
| SMILES | CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc3c(CCNC3=O)n2C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
