| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Perforin-1 |
|---|
| Ligand | BDBM50361411 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_794525 (CHEMBL1936847) |
|---|
| IC50 | 340±n/a nM |
|---|
| Citation |  Spicer, JA; Huttunen, KM; Miller, CK; Denny, WA; Ciccone, A; Browne, KA; Trapani, JA Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem20:1319-36 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Perforin-1 |
|---|
| Name: | Perforin-1 |
|---|
| Synonyms: | PERF_HUMAN | PFP | PRF1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61392.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1285138 |
|---|
| Residue: | 555 |
|---|
| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
|
|
|
|---|
| BDBM50361411 |
|---|
| n/a |
|---|
| Name | BDBM50361411 |
|---|
| Synonyms: | CHEMBL1934375 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H9N3O3S2 |
|---|
| Mol. Mass. | 343.38 |
|---|
| SMILES | O=C1NC(=S)NC1=Cc1csc(n1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| |
|---|
| Structure | 
|
|---|
Search and Browse
