Reaction Details |
| Report a problem with these data |
Target | Perforin-1 |
---|
Ligand | BDBM50361432 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_794525 (CHEMBL1936847) |
---|
IC50 | 800±n/a nM |
---|
Citation | Spicer, JA; Huttunen, KM; Miller, CK; Denny, WA; Ciccone, A; Browne, KA; Trapani, JA Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem20:1319-36 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Perforin-1 |
---|
Name: | Perforin-1 |
Synonyms: | PERF_HUMAN | PFP | PRF1 |
Type: | PROTEIN |
Mol. Mass.: | 61392.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1285138 |
Residue: | 555 |
Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
|
|
|
BDBM50361432 |
---|
n/a |
---|
Name | BDBM50361432 |
Synonyms: | CHEMBL1934396 |
Type | Small organic molecule |
Emp. Form. | C17H10N2O5S |
Mol. Mass. | 354.337 |
SMILES | O=[#6]-1-[#8]-[#6]-c2cc(ccc-12)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)s1 |w:13.15| |
Structure |
|