| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM50361443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_794579 (CHEMBL1936998) |
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| Ki | 5000±n/a nM |
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| Citation |  Kremerovñ, M; Dracínský, M; Hocková, D; Holý, A; Keough, DT; Guddat, LW Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorg Med Chem20:1222-30 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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| Type: | Protein |
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| Mol. Mass.: | 24579.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00492 |
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| Residue: | 218 |
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| Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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| BDBM50361443 |
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| n/a |
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| Name | BDBM50361443 |
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| Synonyms: | CHEMBL1934409 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N5O8P |
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| Mol. Mass. | 377.2472 |
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| SMILES | Nc1nc2n(CC(COCP(O)(O)=O)OCC(O)=O)cnc2c(=O)[nH]1 |
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| Structure | 
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