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TargetSerine/threonine-protein kinase MARK1
LigandBDBM50361642
Substrate/Competitorn/a
Meas. Tech.ChEMBL_799489 (CHEMBL1942297)
IC50 110±n/a nM
Citation Murphy, STAlton, GBailey, SBaxi, SMBurke, BJChappie, TAErmolieff, JFerre, RGreasley, SHickey, MHumphrey, JKablaoui, NKath, JKazmirski, SKraus, MKupchinsky, SLi, JLingardo, LMarx, MARichter, DTanis, SPTran, KVernier, WXie, ZYin, MJYu, XH Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1). J Med Chem54:8490-500 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase MARK1
Name:Serine/threonine-protein kinase MARK1
Synonyms:KIAA1477 | MARK | MARK1 | MARK1_HUMAN
Type:Enzyme
Mol. Mass.:89034.85
Organism:Homo sapiens (Human)
Description:Q9P0L2
Residue:795
Sequence:
MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY
RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV
KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH
RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV
WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG
SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE
VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR
RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP
ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV
ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD
RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF
VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE
IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI
AFKNIASKIANELKL
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  Blast E-value cutoff:
BDBM50361642
n/a
NameBDBM50361642
Synonyms:CHEMBL1940251
TypeSmall organic molecule
Emp. Form.C25H25FN8O2
Mol. Mass.488.5168
SMILESCC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCN(C=O)[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc12 |r|
Structure
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