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TargetHSP90 and hnRNPA2/B1
LigandBDBM50361733
Substrate/Competitorn/a
Meas. Tech.ChEMBL_798935
IC50 14±n/a nM
Citation Baruchello RSimoni DGrisolia GBarbato GMarchetti PRondanin RMangiola SGiannini GBrunetti TAlloatti DGallo GCiacci AVesci LCastorina MMilazzo FMCervoni MLGuglielmi MBBarbarino MFoderà RPisano CCabri W Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90. J Med Chem 54:8592-604 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HSP90 and hnRNPA2/B1
Name:HSP90 and hnRNPA2/B1
Synonyms:HSP 84 | HSP 90 | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) | Heat shock protein HSP 90-beta
Type:Molecular Chaperone
Mol. Mass.:83229.45
Organism:Homo sapiens (Human)
Description:n/a
Residue:724
Sequence:
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
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  Blast E-value cutoff:
BDBM50361733
n/a
NameBDBM50361733
Synonyms:CHEMBL1940943
TypeSmall organic molecule
Emp. Form.C20H25N3O6
Mol. Mass.403.429
SMILESCCNC(=O)c1noc(c1NC(=O)C1CC(O)C1)-c1cc(C(C)C)c(O)cc1O |(4.32,.4,;2.78,.4,;2.02,1.74,;.48,1.75,;-.19,3.13,;-.39,.47,;.12,-.98,;-1.1,-1.92,;-2.37,-1.04,;-1.93,.43,;-2.87,1.65,;-4.41,1.69,;-5.21,.37,;-5.15,3.04,;-4.72,4.52,;-6.2,4.95,;-6.94,6.3,;-6.63,3.47,;-3.7,-1.81,;-5.04,-1.05,;-6.36,-1.82,;-7.7,-1.05,;-7.7,.49,;-9.03,-1.82,;-6.37,-3.36,;-7.7,-4.13,;-5.03,-4.14,;-3.7,-3.36,;-2.36,-4.13,)|
Structure
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