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TargetLysosomal Pro-X carboxypeptidase
LigandBDBM50361773
Substrate/Competitorn/a
Meas. Tech.ChEMBL_799450 (CHEMBL1942258)
IC50 1.4±n/a nM
Citation Graham, THShen, HCLiu, WXiong, YVerras, ABleasby, KBhatt, URChabin, RMChen, DChen, QGarcia-Calvo, MGeissler, WMHe, HLassman, MEShen, ZTong, XTung, ECXie, DXu, SColletti, SLTata, JRHale, JJPinto, SShen, DM The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:658-65 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysosomal Pro-X carboxypeptidase
Name:Lysosomal Pro-X carboxypeptidase
Synonyms:PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:PROTEIN
Mol. Mass.:55028.96
Organism:Mus musculus
Description:ChEMBL_1335505
Residue:491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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  Blast E-value cutoff:
BDBM50361773
n/a
NameBDBM50361773
Synonyms:CHEMBL1938509
TypeSmall organic molecule
Emp. Form.C28H26ClN3O
Mol. Mass.455.979
SMILESC[C@H]([C@H](N)C(=O)NC(c1ccncc1)c1ccc(Cl)cc1)c1ccc(cc1)-c1ccccc1 |r|
Structure
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