| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
|---|
| Ligand | BDBM50361988 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_799098 (CHEMBL1942039) |
|---|
| IC50 | 6±n/a nM |
|---|
| Citation |  Chen, X; Mihalic, J; Deignan, J; Gustin, DJ; Duquette, J; Du, X; Chan, J; Fu, Z; Johnson, M; Li, AR; Henne, K; Sullivan, T; Lemon, B; Ma, J; Miao, S; Tonn, G; Collins, T; Medina, JC Discovery of potent and specific CXCR3 antagonists. Bioorg Med Chem Lett22:357-62 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-X-C chemokine receptor type 3 |
|---|
| Name: | C-X-C chemokine receptor type 3 |
|---|
| Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 40665.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 368 |
|---|
| Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
|
|
|
|---|
| BDBM50361988 |
|---|
| n/a |
|---|
| Name | BDBM50361988 |
|---|
| Synonyms: | CHEMBL1939559 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H27ClF4N4O4S |
|---|
| Mol. Mass. | 651.071 |
|---|
| SMILES | C[C@@H](N(CC1CCS(=O)(=O)CC1)C(=O)Cc1ccc(F)c(c1)C(F)(F)F)c1nc2ncccc2c(=O)n1-c1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
