Reaction Details |
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Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Ligand | BDBM50362047 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_797286 (CHEMBL1942778) |
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Ki | 2300±n/a nM |
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Citation | Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia. Bioorg Med Chem Lett22:235-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
Type: | Enzyme |
Mol. Mass.: | 104751.53 |
Organism: | Homo sapiens (Human) |
Description: | Q9HCR9 |
Residue: | 933 |
Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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BDBM50362047 |
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n/a |
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Name | BDBM50362047 |
Synonyms: | CHEMBL1940057 |
Type | Small organic molecule |
Emp. Form. | C21H28N4O3 |
Mol. Mass. | 384.472 |
SMILES | COCCOc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1 |
Structure |
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