| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Ligand | BDBM50362047 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_798760 (CHEMBL1942895) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia. Bioorg Med Chem Lett22:235-9 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68488.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O76083 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
|
|
|
|---|
| BDBM50362047 |
|---|
| n/a |
|---|
| Name | BDBM50362047 |
|---|
| Synonyms: | CHEMBL1940057 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H28N4O3 |
|---|
| Mol. Mass. | 384.472 |
|---|
| SMILES | COCCOc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
