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TargetDelta-type opioid receptor
LigandBDBM50362313
Substrate/Competitorn/a
Meas. Tech.ChEMBL_797688 (CHEMBL1943908)
IC50 0.900000±n/a nM
Citation McCauley, JPDantzman, CLKing, MMErnst, GEWang, XBrush, KPalmer, WEFrietze, WAndisik, DWHoesch, VDoring, KHulsizer, JBui, KHLiu, JHudzik, TJWesolowski, SS Multiparameter exploration of piperazine derivatives asd-opioid receptor agonists for CNS indications. Bioorg Med Chem Lett22:1169-73 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Delta-type opioid receptor
Name:Delta-type opioid receptor
Synonyms:D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50362313
n/a
NameBDBM50362313
Synonyms:CHEMBL1939739
TypeSmall organic molecule
Emp. Form.C32H35FN4O2
Mol. Mass.526.6443
SMILESFc1ccc(CN2CCN(CC2)[C@H](c2ccc(cc2)C(=O)N2CCC2)c2cccc(NC(=O)C3CC3)c2)cc1 |r|
Structure
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