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TargetMuscarinic acetylcholine receptor M1
LigandBDBM50362374
Substrate/Competitorn/a
Meas. Tech.ChEMBL_797803 (CHEMBL1944259)
IC50>10000±n/a nM
Citation Melancon, BJLamers, APBridges, TMSulikowski, GAUtley, TJSheffler, DJNoetzel, MJMorrison, RDScott Daniels, JNiswender, CMJones, CKConn, PJLindsley, CWWood, MR Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012. Bioorg Med Chem Lett22:1044-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M1
Name:Muscarinic acetylcholine receptor M1
Synonyms:ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:Protein
Mol. Mass.:51442.54
Organism:Homo sapiens (Human)
Description:P11229
Residue:460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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  Blast E-value cutoff:
BDBM50362374
n/a
NameBDBM50362374
Synonyms:CHEMBL1939959
TypeSmall organic molecule
Emp. Form.C18H19ClN6O3S2
Mol. Mass.466.965
SMILESClc1cccc(n1)N1CCN(CC1)C(=O)CCNS(=O)(=O)c1cccc2nsnc12
Structure
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