| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK3 |
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| Ligand | BDBM50362987 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_800413 (CHEMBL1948344) |
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| IC50 | 1100±n/a nM |
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| Citation |  Duffey, MO; Vos, TJ; Adams, R; Alley, J; Anthony, J; Barrett, C; Bharathan, I; Bowman, D; Bump, NJ; Chau, R; Cullis, C; Driscoll, DL; Elder, A; Forsyth, N; Frazer, J; Guo, J; Guo, L; Hyer, ML; Janowick, D; Kulkarni, B; Lai, SJ; Lasky, K; Li, G; Li, J; Liao, D; Little, J; Peng, B; Qian, MG; Reynolds, DJ; Rezaei, M; Scott, MP; Sells, TB; Shinde, V; Shi, QJ; Sintchak, MD; Soucy, F; Sprott, KT; Stroud, SG; Nestor, M; Visiers, I; Weatherhead, G; Ye, Y; D'Amore, N Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem55:197-208 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK3 |
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| Name: | Serine/threonine-protein kinase PLK3 |
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| Synonyms: | CNK | Cytokine-inducible serine/threonine-protein kinase | FGF-inducible kinase | FNK | PLK3 | PLK3_HUMAN | PRK | Polo-Like Kinase 3 | Proliferation-related kinase | Serine/threonine-protein kinase PLK3 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 71655.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Enzyme assays were using PLK3 purified from baculovirus-infected Trichoplusia ni cells expressing full-length PLK3. |
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| Residue: | 646 |
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| Sequence: | MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP
LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
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| BDBM50362987 |
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| n/a |
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| Name | BDBM50362987 |
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| Synonyms: | CHEMBL1945499 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30ClN5S |
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| Mol. Mass. | 480.068 |
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| SMILES | CC(C)c1ccc(CCCN(C)C)cc1Nc1ncc2CC(=S)Nc3cc(Cl)ccc3-c2n1 |
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| Structure | 
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