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TargetSerine/threonine-protein kinase PLK3
LigandBDBM50362981
Substrate/Competitorn/a
Meas. Tech.ChEMBL_800413 (CHEMBL1948344)
IC50 18±n/a nM
Citation Duffey, MOVos, TJAdams, RAlley, JAnthony, JBarrett, CBharathan, IBowman, DBump, NJChau, RCullis, CDriscoll, DLElder, AForsyth, NFrazer, JGuo, JGuo, LHyer, MLJanowick, DKulkarni, BLai, SJLasky, KLi, GLi, JLiao, DLittle, JPeng, BQian, MGReynolds, DJRezaei, MScott, MPSells, TBShinde, VShi, QJSintchak, MDSoucy, FSprott, KTStroud, SGNestor, MVisiers, IWeatherhead, GYe, YD'Amore, N Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem55:197-208 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PLK3
Name:Serine/threonine-protein kinase PLK3
Synonyms:CNK | Cytokine-inducible serine/threonine-protein kinase | FGF-inducible kinase | FNK | PLK3 | PLK3_HUMAN | PRK | Polo-Like Kinase 3 | Proliferation-related kinase | Serine/threonine-protein kinase PLK3
Type:Serine/threonine-protein kinase
Mol. Mass.:71655.17
Organism:Homo sapiens (Human)
Description:Enzyme assays were using PLK3 purified from baculovirus-infected Trichoplusia ni cells expressing full-length PLK3.
Residue:646
Sequence:
MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP
LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
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  Blast E-value cutoff:
BDBM50362981
n/a
NameBDBM50362981
Synonyms:CHEMBL1945171
TypeSmall organic molecule
Emp. Form.C24H26ClN5S
Mol. Mass.452.015
SMILESCN(C)CCCc1ccc(C)c(Nc2ncc3CC(=S)Nc4cc(Cl)ccc4-c3n2)c1
Structure
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