| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B10 |
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| Ligand | BDBM50363057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_800765 (CHEMBL1948101) |
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| IC50 | 280±n/a nM |
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| Citation |  Minehira, D; Takeda, D; Urata, H; Kato, A; Adachi, I; Wang, X; Matsuya, Y; Sugimoto, K; Takemura, M; Endo, S; Matsunaga, T; Hara, A; Koseki, J; Narukawa, K; Hirono, S; Toyooka, N Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1. Bioorg Med Chem20:356-67 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B10 |
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| Name: | Aldo-keto reductase family 1 member B10 |
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| Synonyms: | AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP |
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| Type: | Protein |
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| Mol. Mass.: | 36024.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60218. 1ZUA; 4JII; 4GQ0 |
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| Residue: | 316 |
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| Sequence: | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
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| BDBM50363057 |
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| n/a |
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| Name | BDBM50363057 |
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| Synonyms: | CHEMBL1946962 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15BrF2N2O2S |
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| Mol. Mass. | 465.311 |
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| SMILES | OC(=O)Cn1c2c(CCN(Cc3ccc(Br)cc3F)C2=S)c2cc(F)ccc12 |
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| Structure | 
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