| Reaction Details |
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 | Report a problem with these data |
| Target | TYR_PHOSPHATASE_2 domain-containing protein |
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| Ligand | BDBM50363161 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_801147 (CHEMBL1948974) |
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| IC50 | 81000±n/a nM |
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| Citation |  Chiaradia, LD; Martins, PG; Cordeiro, MN; Guido, RV; Ecco, G; Andricopulo, AD; Yunes, RA; Vernal, J; Nunes, RJ; Terenzi, H Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB). J Med Chem55:390-402 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TYR_PHOSPHATASE_2 domain-containing protein |
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| Name: | TYR_PHOSPHATASE_2 domain-containing protein |
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| Synonyms: | (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB |
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| Type: | Hydrolase |
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| Mol. Mass.: | 30152.45 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | n/a |
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| Residue: | 276 |
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| Sequence: | MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE
VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSIND
AATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGL
DRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLA
AARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
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| BDBM50363161 |
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| n/a |
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| Name | BDBM50363161 |
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| Synonyms: | CHEMBL1946439 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11NO5 |
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| Mol. Mass. | 297.2622 |
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| SMILES | [O-][N+](=O)c1ccccc1\C=C\C(=O)c1ccc2OCOc2c1 |
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| Structure | 
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