| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 5 |
|---|
| Ligand | BDBM50363167 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_801403 (CHEMBL1948133) |
|---|
| IC50 | 1700±n/a nM |
|---|
| Citation |  Huber, K; Brault, L; Fedorov, O; Gasser, C; Filippakopoulos, P; Bullock, AN; Fabbro, D; Trappe, J; Schwaller, J; Knapp, S; Bracher, F 7,8-dichloro-1-oxo-ß-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem55:403-13 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-activated protein kinase 5 |
|---|
| Name: | MAP kinase-activated protein kinase 5 |
|---|
| Synonyms: | MAP kinase-activated protein kinase 5 (PRAK) | MAPK-Activated Protein Kinase 5 (MK5) | MAPK-activated protein kinase 5 | MAPK5_HUMAN | MAPKAP kinase 5 | MAPKAPK5 | PRAK | p38-regulated/activated protein kinase | p38-regulated/activated protein kinase (PRAK) |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 54229.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant MAPKAPK5 was phosphorylated by incubation with active p38alpha before assays. |
|---|
| Residue: | 473 |
|---|
| Sequence: | MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ
EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
|
|
|
|---|
| BDBM50363167 |
|---|
| n/a |
|---|
| Name | BDBM50363167 |
|---|
| Synonyms: | CHEMBL1945559 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16Cl2N4O |
|---|
| Mol. Mass. | 363.241 |
|---|
| SMILES | Cn1c2c(C(C#N)C3(CCNCC3)NC2=O)c2ccc(Cl)c(Cl)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
