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TargetProtein-S-isoprenylcysteine O-methyltransferase
LigandBDBM50363187
Substrate/Competitorn/a
Meas. Tech.ChEMBL_800448 (CHEMBL1948469)
IC50 58000±n/a nM
Citation Majmudar, JDHodges-Loaiza, HBHahne, KDonelson, JLSong, JShrestha, LHarrison, MLHrycyna, CAGibbs, RA Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem20:283-95 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-S-isoprenylcysteine O-methyltransferase
Name:Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:PROTEIN
Mol. Mass.:31943.26
Organism:Homo sapiens (Human)
Description:ChEMBL_956034
Residue:284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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BDBM50363187
n/a
NameBDBM50363187
Synonyms:CHEMBL1946589
TypeSmall organic molecule
Emp. Form.C31H37NO4S
Mol. Mass.519.695
SMILES[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6]-[#6@H](-[#7]-[#6](=O)-c1cccc2c3ccccc3oc12)-[#6](-[#8])=O |r|
Structure
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