| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Ligand | BDBM50363194 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_800448 (CHEMBL1948469) |
|---|
| IC50 | 6700±n/a nM |
|---|
| Citation |  Majmudar, JD; Hodges-Loaiza, HB; Hahne, K; Donelson, JL; Song, J; Shrestha, L; Harrison, ML; Hrycyna, CA; Gibbs, RA Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem20:283-95 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31943.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_956034 |
|---|
| Residue: | 284 |
|---|
| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
|
|
|
|---|
| BDBM50363194 |
|---|
| n/a |
|---|
| Name | BDBM50363194 |
|---|
| Synonyms: | CHEMBL1946775 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H41NO4S |
|---|
| Mol. Mass. | 535.737 |
|---|
| SMILES | [#6]-[#7](-[#6@@H](-[#6]-[#16]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](-[#8])=O)-[#6](=O)-c1ccccc1-[#8]-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
