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TargetG protein-coupled receptor 44
LigandBDBM50363923
Substrate/Competitorn/a
Meas. Tech.ChEMBL_805475
IC50 4±n/a nM
Citation Liu JLi ARWang YJohnson MGSu YShen WWang XLively SBrown MLai SGonzalez Lopez De Turiso FXu QVan Lengerich BSchmitt MFu ZSun YLawlis SSeitz LDanao JWait JYe QTang HLGrillo MCollins TLSullivan TJMedina JC Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. ACS Med Chem Lett 2:326-330 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G protein-coupled receptor 44
Name:G protein-coupled receptor 44
Synonyms:CD_antigen=CD294 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | G-protein coupled receptor 44 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM50363923
n/a
NameBDBM50363923
Synonyms:CHEMBL1951570
TypeSmall organic molecule
Emp. Form.C27H24ClF3N2O7S
Mol. Mass.613.002
SMILESCOc1cc(CC(O)=O)ccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(cc1Cl)C(F)(F)F)C(=O)NC1CCC1
Structure
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