Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50363956 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_803189 (CHEMBL1954900) | ||
IC50 | 60±n/a nM | ||
Citation | Dow, RL; Li, JC; Pence, MP; Gibbs, EM; LaPerle, JL; Litchfield, J; Piotrowski, DW; Munchhof, MJ; Manion, TB; Zavadoski, WJ; Walker, GS; McPherson, RK; Tapley, S; Sugarman, E; Guzman-Perez, A; DaSilva-Jardine, P Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1. ACS Med Chem Lett2:407-412 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50363956 | |||
n/a | |||
Name | BDBM50363956 | ||
Synonyms: | CHEMBL1952025 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H24N4O3 | ||
Mol. Mass. | 380.4403 | ||
SMILES | Nc1ncnc2CCN(C(=O)c12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:18.20,wD:21.24,(26.2,1.37,;26.2,-.17,;24.87,-.94,;24.87,-2.48,;26.21,-3.25,;27.53,-2.49,;28.87,-3.26,;30.21,-2.49,;30.22,-.94,;28.87,-.15,;28.87,1.38,;27.54,-.93,;31.55,-.18,;32.88,-.95,;34.21,-.19,;34.22,1.35,;32.88,2.13,;31.55,1.36,;35.56,2.12,;35.56,3.65,;36.9,4.42,;38.23,3.64,;39.57,4.4,;40.89,3.63,;40.89,2.09,;42.23,4.39,;38.22,2.1,;36.89,1.34,)| | ||
Structure |