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TargetLysosomal Pro-X carboxypeptidase
LigandBDBM50364679
Substrate/Competitorn/a
Meas. Tech.ChEMBL_802882 (CHEMBL1953700)
IC50 0.38±n/a nM
Citation Shen, HCDing, FXJiang, JVerras, AChabin, RMXu, STong, XChen, QXie, DLassman, MEBhatt, URGarcia-Calvo, MMGeissler, WShen, ZMurphy, BAGorski, JNWiltsie, JSinhaRoy, RHale, JJPinto, SShen, DM Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:1550-6 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysosomal Pro-X carboxypeptidase
Name:Lysosomal Pro-X carboxypeptidase
Synonyms:PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:PROTEIN
Mol. Mass.:55028.96
Organism:Mus musculus
Description:ChEMBL_1335505
Residue:491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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  Blast E-value cutoff:
BDBM50364679
n/a
NameBDBM50364679
Synonyms:CHEMBL1951468 | US8785634, 2
TypeSmall organic molecule
Emp. Form.C25H22ClF3N2O3
Mol. Mass.490.902
SMILES[O-][n+]1ccc(Cl)cc1C1OC2(CCN(Cc3ccc(OC(F)(F)F)cc3)CC2)c2ccccc12
Structure
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