Reaction Details |
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Target | Lysosomal Pro-X carboxypeptidase |
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Ligand | BDBM50364684 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_802882 (CHEMBL1953700) |
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IC50 | 1.1±n/a nM |
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Citation | Shen, HC; Ding, FX; Jiang, J; Verras, A; Chabin, RM; Xu, S; Tong, X; Chen, Q; Xie, D; Lassman, ME; Bhatt, UR; Garcia-Calvo, MM; Geissler, W; Shen, Z; Murphy, BA; Gorski, JN; Wiltsie, J; SinhaRoy, R; Hale, JJ; Pinto, S; Shen, DM Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:1550-6 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal Pro-X carboxypeptidase |
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Name: | Lysosomal Pro-X carboxypeptidase |
Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
Type: | PROTEIN |
Mol. Mass.: | 55028.96 |
Organism: | Mus musculus |
Description: | ChEMBL_1335505 |
Residue: | 491 |
Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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BDBM50364684 |
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n/a |
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Name | BDBM50364684 |
Synonyms: | CHEMBL1951473 |
Type | Small organic molecule |
Emp. Form. | C24H22Cl2FN3O |
Mol. Mass. | 458.355 |
SMILES | CC(N1CCC2(CC1)OC(c1cccnc21)c1cc(Cl)cc(Cl)c1)c1ccc(F)cn1 |
Structure |
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