| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
|---|
| Ligand | BDBM50364687 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_802883 (CHEMBL1953701) |
|---|
| IC50 | 351±n/a nM |
|---|
| Citation |  Shen, HC; Ding, FX; Jiang, J; Verras, A; Chabin, RM; Xu, S; Tong, X; Chen, Q; Xie, D; Lassman, ME; Bhatt, UR; Garcia-Calvo, MM; Geissler, W; Shen, Z; Murphy, BA; Gorski, JN; Wiltsie, J; SinhaRoy, R; Hale, JJ; Pinto, S; Shen, DM Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:1550-6 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal Pro-X carboxypeptidase |
|---|
| Name: | Lysosomal Pro-X carboxypeptidase |
|---|
| Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55028.96 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1335505 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
|
|
|
|---|
| BDBM50364687 |
|---|
| n/a |
|---|
| Name | BDBM50364687 |
|---|
| Synonyms: | CHEMBL1951476 | US8785634, 8 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25ClF3N3O2 |
|---|
| Mol. Mass. | 503.944 |
|---|
| SMILES | CC(C)(N1CCC2(CC1)OC(c1cccnc21)c1cc(Cl)ccn1)c1ccc(OC(F)(F)F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
