| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 1 |
|---|
| Ligand | BDBM50364723 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_803066 |
|---|
| IC50 | 5.7±n/a nM |
|---|
| Citation |  Bennett CE; Burnett DA; Greenlee WJ; Knutson CE; Korakas P; Li C; Tulshian D; Wu WL; Bertorelli R; Fredduzzi S; Grilli M; Lozza G; Reggiani A; Veltri A Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain. Bioorg Med Chem Lett 22:1575-8 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 1 |
|---|
| Name: | Metabotropic glutamate receptor 1 |
|---|
| Synonyms: | GRM1 | Metabotropic Glutamate 1a | mGluR1 | metabotropic glutamate 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 132358.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13255 |
|---|
| Residue: | 1194 |
|---|
| Sequence: | MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE
KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI
EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI
PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG
MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM
AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD
IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE
VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS
CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ
RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL
VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN
FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA
KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGG
GQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEE
EDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQ
QQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPL
QLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPD
DSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
|
|
|
|---|
| BDBM50364723 |
|---|
| n/a |
|---|
| Name | BDBM50364723 |
|---|
| Synonyms: | CHEMBL1951662 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14BrN3OS |
|---|
| Mol. Mass. | 400.292 |
|---|
| SMILES | CN(C)c1ccnc2sc3c(ccn(-c4ccc(Br)cc4)c3=O)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
