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TargetProtein-tyrosine kinase 6
LigandBDBM50364832
Substrate/Competitorn/a
Meas. Tech.ChEMBL_803533 (CHEMBL1953281)
IC50>50000±n/a nM
Citation Hada, KSuda, AAsoh, KTsukuda, THasegawa, MSato, YOgawa, KKuramoto, SAoki, YShimma, NIshikawa, TKoyano, H Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem20:1442-60 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-tyrosine kinase 6
Name:Protein-tyrosine kinase 6
Synonyms:BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:Tyrosine-protein kinase
Mol. Mass.:51839.11
Organism:Homo sapiens (Human)
Description:n/a
Residue:451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQG
YVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRD
TQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPH
WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK
KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM
CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS
RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM
LTCWCRDPEQRPCFKALRERLSSFTSYENPT
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  Blast E-value cutoff:
BDBM50364832
n/a
NameBDBM50364832
Synonyms:CHEMBL1949788
TypeSmall organic molecule
Emp. Form.C19H20ClNO4
Mol. Mass.361.819
SMILESCOc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Structure
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