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TargetHeterogeneous nuclear ribonucleoprotein A1
LigandBDBM50008923
Substrate/Competitorn/a
Meas. Tech.ChEMBL_805716 (CHEMBL1960739)
Kd 82.7±n/a nM
Citation Manita, DToba, YTakakusagi, YMatsumoto, YKusayanagi, TTakakusagi, KTsukuda, STakada, KKanai, YKamisuki, SSakaguchi, KSugawara, F Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction. Bioorg Med Chem19:7690-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heterogeneous nuclear ribonucleoprotein A1
Name:Heterogeneous nuclear ribonucleoprotein A1
Synonyms:HNRNPA1 | HNRPA1 | Helix-destabilizing protein | ROA1_HUMAN | Single-strand RNA-binding protein | hnRNP A1 | hnRNP core protein A1
Type:PROTEIN
Mol. Mass.:38757.28
Organism:Homo sapiens (Human)
Description:ChEMBL_805716
Residue:372
Sequence:
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFV
TYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHH
LRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKA
LSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGS
GDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGG
GSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGS
SSSSSYGSGRRF
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  Blast E-value cutoff:
BDBM50008923
n/a
NameBDBM50008923
Synonyms:(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione | (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT) | 4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione | CHEMBL65 | Camptothecin (CT) | camptothecine | cid_24360
TypeSmall organic molecule
Emp. Form.C20H16N2O4
Mol. Mass.348.352
SMILESCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r|
Structure
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