Reaction Details |
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Target | 5-hydroxytryptamine receptor 3A |
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Ligand | BDBM50365257 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_805902 (CHEMBL1960083) |
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Ki | 12±n/a nM |
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Citation | Tao, M; Aimone, LD; Huang, Z; Mathiasen, J; Raddatz, R; Lyons, J; Hudkins, RL Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H3 receptor antagonists with potent cognition enhancing activity. J Med Chem55:414-23 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 3A |
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Name: | 5-hydroxytryptamine receptor 3A |
Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 55428.70 |
Organism: | RAT |
Description: | 5-HT3 HTR3A RAT::P35563 |
Residue: | 483 |
Sequence: | MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
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BDBM50365257 |
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n/a |
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Name | BDBM50365257 |
Synonyms: | CHEMBL1958330 |
Type | Small organic molecule |
Emp. Form. | C24H28N4O2 |
Mol. Mass. | 404.5047 |
SMILES | O=c1cc(cnn1-c1ccccn1)-c1ccc(OCCCN2CCCCCC2)cc1 |
Structure |
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